Product Name :
LX-1031
Description:
LX-1031 is a THP inhibitor (a tryptophan 5-hydroxylase inhibitor) that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. LX-1031 has potential for illnesses characterized by excess 5-HT, such as diarrhea-predominant irritable bowel syndrome (IBS-D) and carcinoid diarrhea. In vitro, inhibition of TPH1 occurred in 10(-8) -10(-7) mol L(-1) range. In vivo in rodents, LX-1031 has no effect on brain 5-HT while dose-dependently reducing 5-HT, particularly in the small bowel.
CAS:
945976-76-1
Molecular Weight:
538.52
Formula:
C28H25F3N4O4
Chemical Name:
(2S)-2-amino-3-(4-2-amino-6-[(1R)-2,2,2-trifluoro-1-3′-methoxy-[1,1′-biphenyl]-4-ylethoxy]pyrimidin-4-ylphenyl)propanoic acid
Smiles :
COC1=CC(=CC=C1)C1C=CC(=CC=1)[C@@H](OC1=CC(=NC(N)=N1)C1C=CC(C[C@H](N)C(O)=O)=CC=1)C(F)(F)F
InChiKey:
XNMUICFMGGQSMZ-WIOPSUGQSA-N
InChi :
InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22-,25+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Toceranib Data Sheet
Shelf Life:
≥360 days if stored properly.Vericiguat Purity & Documentation
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LX-1031 is a THP inhibitor (a tryptophan 5-hydroxylase inhibitor) that reduces 5-HT levels for the potential treatment of irritable bowel syndrome. LX-1031 has potential for illnesses characterized by excess 5-HT, such as diarrhea-predominant irritable bowel syndrome (IBS-D) and carcinoid diarrhea. In vitro, inhibition of TPH1 occurred in 10(-8) -10(-7) mol L(-1) range. In vivo in rodents, LX-1031 has no effect on brain 5-HT while dose-dependently reducing 5-HT, particularly in the small bowel.|Product information|CAS Number: 945976-76-1|Molecular Weight: 538.52|Formula: C28H25F3N4O4|Chemical Name: (2S)-2-amino-3-(4-2-amino-6-[(1R)-2,2,2-trifluoro-1-3′-methoxy-[1,1′-biphenyl]-4-ylethoxy]pyrimidin-4-ylphenyl)propanoic acid|Smiles: COC1=CC(=CC=C1)C1C=CC(=CC=1)[C@@H](OC1=CC(=NC(N)=N1)C1C=CC(C[C@H](N)C(O)=O)=CC=1)C(F)(F)F|InChiKey: XNMUICFMGGQSMZ-WIOPSUGQSA-N|InChi: InChI=1S/C28H25F3N4O4/c1-38-21-4-2-3-20(14-21)17-9-11-19(12-10-17)25(28(29,30)31)39-24-15-23(34-27(33)35-24)18-7-5-16(6-8-18)13-22(32)26(36)37/h2-12,14-15,22,25H,13,32H2,1H3,(H,36,37)(H2,33,34,35)/t22-,25+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33025417 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|