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Eye (2016) 30, 1579587 2016 Macmillan Publishers Restricted, part of Springer Nature. All rights reserved 0950-222X/16 nature.com/eyeMicrovascular endothelial function and severity of major open angle glaucomaAbstract Purpose The part of microvascular endothelial dysfunction on severity of key open angle glaucoma (POAG) was investigated in this study. Patients and methods A prospective cohort study was carried out. A single hundred and fourteen ethnically Malay individuals (114 eyes) with POAG treated at the eye clinic of Hospital University Sains Malaysia in between April 2012 and December 2014 have been recruited. Patients aged between 40 and 80 years with two consecutive reputable and reproducible Humphrey visual field 24-2 analyses have been chosen. Patients who were diagnosed with any other style of glaucoma, earlier glaucoma-filtering surgery, or other surgeries except uncomplicated cataract and pterygium surgery were excluded. Humphrey visual field analysis 24-2 was used to stratify the severity of glaucoma applying Sophisticated Glaucoma Intervention Study (AGIS) score in the time of recruitment. Microvascular endothelial function was assessed using Laser Doppler fluximetry and iontophoresis.NOTCH1 Protein web Iontophoresis course of action with acetylcholine (ACh) and sodium nitroprusside (SNP) was applied to measure microvascular endotheliumdependent and -independent vasodilatation, respectively. Final results Primarily based around the AGIS score, 55 sufferers showed mild glaucoma, with 29 moderate and 30 severe. There was statistically considerable distinction in microvascular endothelial function (ACh and AChmax) between mild and moderate POAG cases (P = 0.023) and amongst mild and severe POAG instances (Po0.001).BMP-7 Protein custom synthesis There was negative correlation involving microvascular endothelial function and severity of POAG (r = – 0.PMID:24423657 457, Po0.001). Conclusion Microvascular endothelial dysfunction may have a role in influencing the severity of POAG in Malay individuals.SMI Bukhari1, KY Kiu1, R Thambiraja1, S Sulong2, AHG Rasool3 and AT Liza-SharminiCLINICAL STUDYEye (2016) 30, 1579587; doi:ten.1038/eye.2016.185; published on-line 19 August 2016 Introduction Glaucoma is a complicated multi-factorial illness major to irreversible blindness. The pressuredependent (mechanical) and pressureindependent (vascular) theories have already been postulated to possess vital part in glaucomatous optic neuropathy.1 Pressureindependent mechanism holds imbalance of the optic nerve head (ONH) perfusion responsible for ischemia within the retinal nerve fiber layer (RNFL).two,three ONH perfusion can be affected by ocular perfusion pressure (OPP). OPP is dynamic but is usually mathematically calculated working with systemic blood pressure and intraocular pressure (IOP). OPP is affected by the resistance to flow and regulated by the size (caliber) of vessel lumen.four The advancement of technology has created the visualization of ocular blood flow doable applying several techniques: colour Doppler ultrasound imaging,5 scanning laser ophthalmoscopic angiography,6 confocal scanning laser Doppler flowmetry,7 and retinal vessel analyzer (RVA).eight These strategies measure different aspect of ocular blood flow but are certainly not precise to quantify the blood flow to ONH. There was also a lack of gold regular as r.