Product Name :
Rabbit anti-C1orf51 Polyclonal Antibody(N-term)
Synonym :
Circadian-associated transcriptional repressor; ChIP-derived repressor of network oscillator; Chrono; Computationally highlighted repressor of the network oscillator; CIART; C1orf51
Host :
Rabbit
Species Reactivity:
Human
Specificity :
This C1orf51 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human C1orf51.
Predicted Reactivity:
Applications :
WB~~1:1000IHC-P~~1:50~100FC~~1:10~50
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Cell Biology
Background :
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5′-CACGTG-3′) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).
UniProt :
Q8N365
Additional information:
Product Details FAQ Citations(1) Video Pictures Documents |Overview |Description Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |Synonym Circadian-associated transcriptional repressor; ChIP-derived repressor of network oscillator; Chrono; Computationally highlighted repressor of the network oscillator; CIART; C1orf51 |Host Rabbit |Specificity This C1orf51 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human C1orf51. |Species Reactivity Human |Applications WB~~1:1000IHC-P~~1:50~100FC~~1:10~50 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Cell Biology |Target |Background Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5′-CACGTG-3′) on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). |Cellular localization Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body. |UniProt Q8N365 |References |References Lamesch, P., et al. Genomics 89(3):307-315(2007) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-C1orf51 Polyclonal Antibody(N-term)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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