Product Name :
CRA-2059
Description:
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ).
CAS:
256649-36-2
Molecular Weight:
750.80
Formula:
C34H46N12O8
Chemical Name:
(3R,6R)-6-(4-[(4-carbamimidamidophenyl)methyl]carbamoylpiperazine-1-carbonyloxy)-hexahydrofuro[3,2-b]furan-3-yl 4-[(4-carbamimidamidophenyl)methyl]carbamoylpiperazine-1-carboxylate
Smiles :
NC(=N)NC1C=CC(CNC(=O)N2CCN(CC2)C(=O)O[C@@H]2COC3C2OC[C@H]3OC(=O)N2CCN(CC2)C(=O)NCC2C=CC(=CC=2)NC(N)=N)=CC=1
InChiKey:
SDKLWMXBZVGUHI-XPALAHHGSA-N
InChi :
InChI=1S/C34H46N12O8/c35-29(36)41-23-5-1-21(2-6-23)17-39-31(47)43-9-13-45(14-10-43)33(49)53-25-19-51-28-26(20-52-27(25)28)54-34(50)46-15-11-44(12-16-46)32(48)40-18-22-3-7-24(8-4-22)42-30(37)38/h1-8,25-28H,9-20H2,(H,39,47)(H,40,48)(H4,35,36,41)(H4,37,38,42)/t25-,26-,27?,28?/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ).|Product information|CAS Number: 256649-36-2|Molecular Weight: 750.80|Formula: C34H46N12O8|Chemical Name: (3R,6R)-6-(4-[(4-carbamimidamidophenyl)methyl]carbamoylpiperazine-1-carbonyloxy)-hexahydrofuro[3,2-b]furan-3-yl 4-[(4-carbamimidamidophenyl)methyl]carbamoylpiperazine-1-carboxylate|Smiles: NC(=N)NC1C=CC(CNC(=O)N2CCN(CC2)C(=O)O[C@@H]2COC3C2OC[C@H]3OC(=O)N2CCN(CC2)C(=O)NCC2C=CC(=CC=2)NC(N)=N)=CC=1|InChiKey: SDKLWMXBZVGUHI-XPALAHHGSA-N|InChi: InChI=1S/C34H46N12O8/c35-29(36)41-23-5-1-21(2-6-23)17-39-31(47)43-9-13-45(14-10-43)33(49)53-25-19-51-28-26(20-52-27(25)28)54-34(50)46-15-11-44(12-16-46)32(48)40-18-22-3-7-24(8-4-22)42-30(37)38/h1-8,25-28H,9-20H2,(H,39,47)(H,40,48)(H4,35,36,41)(H4,37,38,42)/t25-,26-,27?,28?/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Alectinib MedChemExpress |Shelf Life: ≥12 months if stored properly.5-Ethynyluridine web |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33151655 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research.|References:|Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002;16(3):407-413.Selwood T, et al. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor. Biol Chem. 2003;384(12):1605-1611.Products are for research use only. Not for human use.|