One explanation is that L1 phosphorylation is promoted by initial interactions between 14-3-3f and (non-phosphorylated) L1ICD, resulting in L1ICD conformational changes and, consequently

Notably, phosphorylation of L1ICD at Ser1181 by CKII was profoundly increased by 143-3f. One clarification is that L1 phosphorylation is promoted by preliminary interactions amongst fourteen-3-3f and (non-phosphorylated) L1ICD, ensuing…