In buy to build no matter whether Jak2 and STAT5b can stabilize every single other we also co-expressed the two proteins and analyzed their conduct at elevated temperature Fig four, lower panel, reveals that this is not the case

Thus, incubation at 40uC reduced the signaling capacity of cells substantially, most likely because of to the reduction of the two Jak2 and STAT5b degrees.Since Triton-soluble Jak2 protein amounts had…