Mouse CLEC12A/MICL/CLL-1 Protein 4201

Additional Information:
accession Q504P2|express systemHEK293|product tagN-His|purity> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC|backgroundCLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML.|molecular weightThe protein has a predicted MW of 24.9 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Mouse CLEC12A/MICL/CLL-1 Protein 4201proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceCLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML.Protein namesC-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371)Gene namesClec12a,Clec12a MiclMass30757DaFunctionCell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.Subellular locationCell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization.StructureInteracts with PTPN6 and PTPN11.DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-baTarget Relevance information above includes information from UniProt accession: Q504P2The UniProt Consortium|