Product Name :
EPAC 5376753
Description:
EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.
CAS:
302826-61-5
Molecular Weight:
367.21
Formula:
C15H8Cl2N2O3S
Chemical Name:
5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione
Smiles :
O=C1NC(=S)NC(=O)C1=CC1=CC=C(O1)C1=CC=C(Cl)C=C1Cl
InChiKey:
QQAOFKJHOUFHKI-UHFFFAOYSA-N
InChi :
InChI=1S/C15H8Cl2N2O3S/c16-7-1-3-9(11(17)5-7)12-4-2-8(22-12)6-10-13(20)18-15(23)19-14(10)21/h1-6H,(H2,18,19,20,21,23)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{MIF Protein, Human} MedChemExpress|{MIF Protein, Human} Protocol|{MIF Protein, Human} Formula|{MIF Protein, Human} custom synthesis|{MIF Protein, Human} Autophagy}
Shelf Life:
≥12 months if stored properly.{{SQ109} web|{SQ109} Bacterial|{SQ109} TGF-beta/Smad|{SQ109} Purity & Documentation|{SQ109} In Vitro|{SQ109} supplier}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32351194
Additional information:
EPAC 5376753 is an allosterically inhibitor of Epac which inhibits Epac1 with an IC50 of 4 µM in Swiss 3T3 cells.|Product information|CAS Number: 302826-61-5|Molecular Weight: 367.21|Formula: C15H8Cl2N2O3S|Chemical Name: 5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-2-sulfanylidene-1,3-diazinane-4,6-dione|Smiles: O=C1NC(=S)NC(=O)C1=CC1=CC=C(O1)C1=CC=C(Cl)C=C1Cl|InChiKey: QQAOFKJHOUFHKI-UHFFFAOYSA-N|InChi: InChI=1S/C15H8Cl2N2O3S/c16-7-1-3-9(11(17)5-7)12-4-2-8(22-12)6-10-13(20)18-15(23)19-14(10)21/h1-6H,(H2,18,19,20,21,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Epac is a key mediator of cAMP signaling. EPAC 5376753, the thiobarbituric acid modification of 5225554, has a greater ability to decrease the conformational changes of Epac necessary for its activation and to inhibit Epac signaling in cells. 5376753 selectively inhibits Epac-mediated migration in fibroblasts.|Products are for research use only. Not for human use.|