Product Name :
EUK 134
Description:
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, has exhibited potent antioxidant activities and inhibited the formation of β-amyloid and related amyloid fibril. In vitro:EUK-134, a salen-manganese complex, showed potent catalase and cytoprotective activities and SOD activity. After middle cerebral artery occlusion, EUK-134 administration at 3 hr significantly reduced brain infarct size, with the highest dose apparently preventing further infarct growth. Administration of EUK 134 (20 μM) prevented Aβ-induced microglial proliferation in vitro. In human neuroblastoma cell line SK-N-MC, pre-treatments with EUK134 protected cells against H2O2-induced oxidative stress through inhibition of MAPK pathway in a dose-dependent manner.EUK134 also decreased the expression of pro-apoptotic genes p53 and Bax and enhanced expression of anti-apoptotic Bcl-2 gene . Incubation of human amylin with EUK-134 significantly inhibited amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). In vivo:Compared to the vehicle-injected rats, the EUK-134-treated group at doses of 0.5 and 5.0 μmol/kg (0.25 and 2.5 mg/kg, respectively) exhibited infarct volumes that were significantly lower than those of vehicle-injected rats. At 5.0 μmol/kg, EUK-134 reduced the infarct volume by 90% when compared with that of the vehicle controls .EUK-134 protected most of the vulnerable neurons from excitotoxic cell death.EUK-134 significantly reduced (P< 0.05) KA-induced neuronal damage in CA1 (22% of total neurons), an almost complete protection in CA3 (7%) and piriform cortex (14%), indicating that EUK-134 prevented most but not all neuronal damage resulting from KA-induced seizure activity .
CAS:
81065-76-1
Molecular Weight:
416.74
Formula:
C18H18ClMnN2O4
Chemical Name:
manganese(2+) 2-methoxy-6-{[(2-{[(3-methoxy-2-oxidophenyl)methylidene]amino}ethyl)imino]methyl}benzen-1-olate chloride
Smiles :
[Cl-].[Mn+2].COC1=CC=CC(C=NCCN=CC2C=CC=C(OC)C=2[O-])=C1[O-]
InChiKey:
ZCNKLAVGNJEDNF-GAMUHHASSA-K
InChi :
InChI=1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+2/p-3/b19-11+,20-12+;;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, has exhibited potent antioxidant activities and inhibited the formation of β-amyloid and related amyloid fibril. In vitro:EUK-134, a salen-manganese complex, showed potent catalase and cytoprotective activities and SOD activity. After middle cerebral artery occlusion, EUK-134 administration at 3 hr significantly reduced brain infarct size, with the highest dose apparently preventing further infarct growth. Administration of EUK 134 (20 μM) prevented Aβ-induced microglial proliferation in vitro.{{Masofaniten} MedChemExpress|{Masofaniten} Vitamin D Related/Nuclear Receptor|{Masofaniten} Activator|{Masofaniten} Protocol|{Masofaniten} Purity|{Masofaniten} custom synthesis} In human neuroblastoma cell line SK-N-MC, pre-treatments with EUK134 protected cells against H2O2-induced oxidative stress through inhibition of MAPK pathway in a dose-dependent manner.{{Diethylstilbestrol} MedChemExpress|{Diethylstilbestrol} Apoptosis|{Diethylstilbestrol} Purity & Documentation|{Diethylstilbestrol} References|{Diethylstilbestrol} custom synthesis|{Diethylstilbestrol} Epigenetics} EUK134 also decreased the expression of pro-apoptotic genes p53 and Bax and enhanced expression of anti-apoptotic Bcl-2 gene .PMID:24761411 Incubation of human amylin with EUK-134 significantly inhibited amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein). In vivo:Compared to the vehicle-injected rats, the EUK-134-treated group at doses of 0.5 and 5.0 μmol/kg (0.25 and 2.5 mg/kg, respectively) exhibited infarct volumes that were significantly lower than those of vehicle-injected rats. At 5.0 μmol/kg, EUK-134 reduced the infarct volume by 90% when compared with that of the vehicle controls .EUK-134 protected most of the vulnerable neurons from excitotoxic cell death.EUK-134 significantly reduced (PProduct information|CAS Number: 81065-76-1|Molecular Weight: 416.74|Formula: C18H18ClMnN2O4|Chemical Name: manganese(2+) 2-methoxy-6-{[(2-{[(3-methoxy-2-oxidophenyl)methylidene]amino}ethyl)imino]methyl}benzen-1-olate chloride|Smiles: [Cl-].[Mn+2].COC1=CC=CC(C=NCCN=CC2C=CC=C(OC)C=2[O-])=C1[O-]|InChiKey: ZCNKLAVGNJEDNF-GAMUHHASSA-K|InChi: InChI=1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+2/p-3/b19-11+,20-12+;;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|