Product Name :
N-Benzylacetamidine (hydrobromide)
Description:
IC50: 0.20 μM: inhibits inducible nitric oxide synthases (iNOS). IC50: 350 μM: blocks endothelial nitric oxide synthases (eNOS). N-Benzylacetamidine is a potent and selective inhibitor of iNOS compared to eNOS. NOS is essential to the formation of nitric oxide (NO) via the NADPH- and O2-dependent oxidation of L-arginine, which plays a role in regulating many pathological and physiological processes, including smooth muscle relaxation and neurotransmission. INOS contributes to immune response and inflammation while eNOS plays a vital role in regulating vascular tone. In vitro: N-Benzylacetamidine showed good iNOS and almost negligible eNOS inhibition in THP-1 cells, a human myelomonocytic leukemia cell line . In vivo: Up to now, in vivo study of N-Benzylacetamidine is still in the development stage.
CAS:
186545-76-6
Molecular Weight:
229.12
Formula:
C9H13BrN2
Chemical Name:
N-benzylethanimidamide hydrobromide
Smiles :
Br.CC(=N)NCC1C=CC=CC=1
InChiKey:
RUQJDXJQOUUQHG-UHFFFAOYSA-N
InChi :
InChI=1S/C9H12N2.BrH/c1-8(10)11-7-9-5-3-2-4-6-9;/h2-6H,7H2,1H3,(H2,10,11);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IC50: 0.20 μM: inhibits inducible nitric oxide synthases (iNOS). IC50: 350 μM: blocks endothelial nitric oxide synthases (eNOS). N-Benzylacetamidine is a potent and selective inhibitor of iNOS compared to eNOS.{{5-Ethynyl-2′-deoxyuridine} medchemexpress|{5-Ethynyl-2′-deoxyuridine} PROTAC Linkers|{5-Ethynyl-2′-deoxyuridine} TGF-beta/Smad|{5-Ethynyl-2′-deoxyuridine} Technical Information|{5-Ethynyl-2′-deoxyuridine} In stock|{5-Ethynyl-2′-deoxyuridine} custom synthesis} NOS is essential to the formation of nitric oxide (NO) via the NADPH- and O2-dependent oxidation of L-arginine, which plays a role in regulating many pathological and physiological processes, including smooth muscle relaxation and neurotransmission.{{Fluphenazine} medchemexpress|{Fluphenazine} Sodium Channel|{Fluphenazine} Biological Activity|{Fluphenazine} In stock|{Fluphenazine} manufacturer|{Fluphenazine} Autophagy} INOS contributes to immune response and inflammation while eNOS plays a vital role in regulating vascular tone.PMID:24187611 In vitro: N-Benzylacetamidine showed good iNOS and almost negligible eNOS inhibition in THP-1 cells, a human myelomonocytic leukemia cell line . In vivo: Up to now, in vivo study of N-Benzylacetamidine is still in the development stage.|Product information|CAS Number: 186545-76-6|Molecular Weight: 229.12|Formula: C9H13BrN2|Chemical Name: N-benzylethanimidamide hydrobromide|Smiles: Br.CC(=N)NCC1C=CC=CC=1|InChiKey: RUQJDXJQOUUQHG-UHFFFAOYSA-N|InChi: InChI=1S/C9H12N2.BrH/c1-8(10)11-7-9-5-3-2-4-6-9;/h2-6H,7H2,1H3,(H2,10,11);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|